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課程名稱 |
高等化學生物學專論二
DISCUSSION IN ADVANCED CHEMICAL BIOLOGY(II) |
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開課學期 |
98-2 |
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授課對象 |
理學院 化學所化學生物學組 |
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授課教師 |
林俊宏 |
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課號 |
Chem8036 |
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課程識別碼 |
223ED1620 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期五2,3,4(9:10~12:10) |
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上課地點 |
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備註 |
本課程以英語授課。化學系有機組不得修習此門。化學系化生組3選1必修。TIGP-CB組必修課程。上課教室：普505。
限博士班
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/982advchembio2 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
This courses aim to provide students with general knowledge in the synthesis of biomolecules, which is applied either to prepare small molecules to probe target DNA/proteins, or to develop efficient methods to study biological questions. Therefore one half of the time is used to cover the synthesis, while the other half is to talk about their applications. |
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課程目標 |
Students who want to take the course need to pass the undergraduate course of organic chemistry (two semester courses with at least 2 hours per week). It is also recommended to have basic concept in biochemistry, at least to be aware of what are the structures of amino acids, nucleic acids and sugars. |
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課程要求 |
Week Content Book/Chapter(s)
1st, Feb 25 Introduction (I)-Chap 1
2nd, Mar 5 Carbohydrate synthesis: protection chemistry (II)-Chap 15
3rd, Mar 12 Carbohydrate synthesis: glycosylation
4th, Mar 19 Solid phase peptide synthesis (I)-Chap 5
5th, Mar 26 Native chemical ligation (II)-Chap 11
6th, Apr 2 Solid phase synthesis of nucleic acids (I)-Chap 2 & 3
Apr 9 Holiday?
7th, Apr 16 Combinatorial synthesis and compound collections for chemical biology (I)-Chap 12 &
(II)-Chap 3
8th, Apr 23 Mid-term exam
9th, Apr 30 Activity-based protein profiling (II)-Chap 5
10th, May 7 Microarray-based strategies (II)-Chap 2
11th, May 14 Proteome analysis (I)-Chap 10
12th, May 21 Antiviral agents (III)- p. 148, p 150
May 28 Take one day off
13th, Jun 4 Reproductive medicine (III)- p. 92, p 94
14th, Jun 11 Drugs for cardiovascular diseases (III)- p. 64, p 69
15th, Jun 18 To be announced
16th, Jun 25 Final exam |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
Textbooks:
(1) Chemical Biology: A practical course (by Waldmann, H.; Janning P.), Wiley-VCH, 2004.
(2) Chemical Biology: Learning through case studies (by Waldmann, H.; Janning P.), Wiley-VCH, 2009.
(3) Molecules and Medicine (by Corey, E. J.; Czakó, B.; Kürti. L.), Wiley, 2007.
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參考書目 |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
2/26 |
syllabus |
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第11週 |
5/07 |
mid-term answer key |
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第18週 |
06/25 |
powerpoint files from students |
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